Low-Dose Naltrexone and Thyroid Disease: A Promising Connection

Low-dose naltrexone (LDN) has been gaining attention as a potential supportive therapy for many conditions including thyroid disease, and particularly autoimmune conditions like Hashimoto’s thyroiditis. But what exactly is Low Dose Naltrexone, and how might it help those struggling with thyroid issues? Let’s dive in!

What Is Low-Dose Naltrexone?

Naltrexone is a medication traditionally used in higher doses to treat opioid addiction and alcohol dependence. At low doses (typically 1.5–4.5 mg), LDN works differently, acting as an immune modulator. It temporarily blocks opioid receptors, which may boost endorphin production and balance immune responses, potentially reducing inflammation and autoimmune activity.

Low Dose Naltrexone and Thyroid Disease

In thyroid diseases like Hashimoto’s, the immune system attacks the thyroid gland, leading to hypothyroidism and symptoms such as fatigue, weight gain, and brain fog. While LDN isn’t a cure, early research and anecdotal reports suggest it may:

• Reduce Autoimmune Activity: LDN may lower thyroid antibodies (like TPO and TG) by calming an overactive immune system.
• Ease Symptoms: Some patients report improved energy, mood, and pain levels, which are common complaints in thyroid disorders.
• Support Overall Wellness: By promoting endorphin release, LDN may enhance a sense of well-being, which can be a game-changer for chronic conditions.

Studies on LDN for thyroid disease are limited, but its use in other autoimmune conditions, like multiple sclerosis or Crohn’s disease, shows promise. Always consult a healthcare provider before starting LDN, as it’s typically prescribed off-label and requires personalized dosing and monitoring. The LDN Research Trust is a great organization to learn more about all of the conditions LDN is being used to treat and how it works. 

Low-dose naltrexone is something I prescribe for many patients with autoimmune disease, chronic pain, long COVID and more! It is an intriguing option for managing thyroid disease, especially for those with autoimmune-driven conditions like Hashimoto’s. While more research is needed, its tolerability along with its potential to reduce inflammation and improve symptoms makes it worth considering! To learn more about Well North Functional Medicine and how you can work with us, book a FREE discovery call below!